Pharmacogenetics of response to simvastatin in Chinese patients with hyperlipidaemia
作者单位：Department of Medicine & TherapeuticsChinese University of Hong Kong Department of Chemical PathologyChinese University of Hong Kong School of PharmacyFaculty of MedicineChinese University of Hong Kong
会议名称：《两岸三地药理学与临床药理学术会议》
会议日期：2008年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100602[医学-中西医结合临床] 10[医学]
关 键 词：pharmacogenetics simvastatin Adiponectin LDL-Receptor
摘 要：Objective To examine the relationship of single-nucleotide polymorphisms(SNPs)in candidate genes with the lipid responses to *** Chinese patients were treated with simvastatin 40 mg daily for at least 6 weeks.20 SNPs in 11 genes were *** 95 patients age(mean±SD) 57.5±10.6 years completed the *** Adiponectin 45TG polymorphism was significantly re- lated to absolute reductions in total cholesterol(TC)and LDL-cholesterol with a trend(P=0.053)for percentage reductions in TC(TT:TG:GG=-38.4%:-35.6%:-32.6%).Similar findings were seen with LDL-Receptor(LDLR)SNPs(2052TC and 1866CT)with absolute reductions in TC and LDL-cholesterol significantly *** Breast Cancer Resistance Protein(ABCG2)421CA poly- morphism was related(P0.05)to HDL-cholesterol response(CC:CA:AA=+0.50%:-5.73%:- 11.41%).Conclusions Adiponectin,LDLR and ABCG2 SNPs had some influence on the lipid responses to simvastatin.