Effect of Sitagliptin Metformin HCL on glucose fluctuation in patients with type 2 diabetes with premixed Insulin therapy
作者单位：Qingdao Endocrine & Diabetes Hospital Weifang Medical University
会议名称：《中华医学会第十二次全国内分泌学学术会议》
会议日期：2013年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Aim To investigate the effect of Sitagliptin Metformin HCL,a combination tablet containing dipeptidylpeptide-4 (DDP-4) inhibitor and metformin,on glycemic control and glucose fluctuation when added on the ongoing premixed insulin analog therapy in patients with type 2 diabetes(T2DM). Methods A total of 46 outpatients(mean age 56.5±11.3 yrs,mean duration 9.5±4.1 yrs,mean BMI 26.8±3.6kg/m, %of men 46.3%) who had blood glucose fluctuation under the combination therapy of premixed insulin analog(21 on insulin lispro 25R and 25 on insulin aspart 30) and metformin over 3