Effects of Chinese patent medicines on restenosis after percutaneous coronary intervention
会议名称：《第三届中日双边药理学和临床药理学学术会议》
会议日期：2007年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
摘 要：正AIM Percutaneous coronary intervention （PCI） is an effective approach to coronary heart disease （CHD）,which significantly reduce the mortality and the complication incidences in admission,however restenosis, no-reflow and recurrent cardiovascular events,etc.,after successful PCT have became a great challenge for CHD *** changes associated with restenosis, such as vascular intimal thickening,platelet activation, endothelial dysfunction,and so on,are related to blood stasis according to basic theory of traditional Chinese med- icine （TCM）.So we have investigated the effect of Chinese patent medicines （CPM） with the action of blood- activating and stasis-resolving on restenosis after PCI from *** experiments proved CPM inhibited neointi- mal hyperplasia and prevented vascular remodeling,and which improved symptoms and the long-term prognosis of CHD patients with successful PCT in a small sample clini- cal *** order to objectively evaluate clinical signifi- cance of CPM to post-PCI patients,we conducted a multi- center,randomized,double-blind,placebo-controlled tri- *** A total of 335 patients were randomized into treatment with the oral administration of Xiongshao capsule （consist of effective components extracted from both Chuanxiongol and paeoniflorin which are common used in TCM clinical practice to promote blood circula- tion）,or a placebo for 6 months after successful ***- giographic follow-up was scheduled at 6 months,and clini- cal follow-up performed at 1,3 and 6 months after PCI. The primary end points were angiographic restenosis,and the combined incidence of *** secondary end points were target lesion,nonfatal myocardial infarction, repeat angioplasty,and coronary artery bypass graft surgery. RESULTS A total of 308 patients （91.9%） completed the study and 145 cases （47.1%） received angiographic *** restenosis rates were significantly reduced in the Xiongshao capsule group as compared with the pla-