P - glycoprotein restricted transport of nimodipine across the blood - brain barrier
会议名称：《第八届全国生化药理学术讨论会暨第七届Servier奖颁奖大会会议》
会议日期：2003年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：P-glycoprotein (P-gP) located in brain capillary endothelial cell membranes has been thought to function as a component of the blood-brain barrier (BBB). Nimodipine (NMD) was a calcium antagonist of dihydropyridine and was successfully used to treat central nervous system disorders. Because NMD is also a substrate of P-gp, which suggested that NMD transports across BBB may be modulated by P-gp. In this study, the uptake and efflux of NMD by primary cultured rat brain capillary endothelial cells (BCEC) were investigated in order to examine whether the transport of NMD from the