SLC17A7 gene may be the indicator of SSRIs treatment response in the Chinese Han popultaion
作者单位：Bio-X InstitutesKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong University Mental Health CenterWest China HospitalSichuan University
会议名称：《第十二次全国医学遗传学学术会议》
会议日期：2013年
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
关 键 词：Major depressive disoreder VGLUT1 SLC17A7 pharmacogenetics
摘 要：Objective To investigate whether genetic polymophisms in SLC17A7 gene is associated with serotonin reuptake inhibitors(SSRI) treatment response of major depressive disorder *** A total of 290 depressed patients,age 18-55 years,fulfilling the DSM-Ⅳdiagnostic criteria for major depressive disorder,with a minimum HAMD score at 18, were recruited for this *** patients were randomly treated with 4 SSRIs and received a 6-week period of *** was defined as a 50%of the reducing scores rate of HAMD scores at the end of the 6th *** single nucleotide polymorphisms(SNPs) in SLC17A7 gene selected from either the HapMap Chinese ethnic group or the literature report were *** There were two SNPs(rs1578944,rs74174284) associated with response to antidepressant treatment,but only rs74174284 remained significant after correcting for multiple testes using FDR method(FDR p=0.032).The haplotype C-C of rs74174284-rs1578944 showed less non-responder than responders(p=0.0086),while the haplotype G-T showed more non-responders than responders(p=0.0034).Conclusions Our results suggest that genetic variants in the SLC17A7 gene may be indicators of treatment response in MDD patients treated by SSRIs.