Multiple genes encoding fluoroquinolone resistance co-located with ESBL genes in non-typhoidal salmonella isolated from food producing animals
会议名称：《中国药理学会第十一届全国化疗药理学术研讨会》
会议日期：2012年
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100403[医学-营养与食品卫生学] 10[医学]
关 键 词：plasmid Salmonella fluoroquinolone ESBL
摘 要：OBJECTIVES To investigate the molecular epidemiology of genes that confer resistance to fluoroquinolones and extended spectrum(1 -lactams in non-typhoidal Salmonella(NTS) from food producing animals in *** Thirty-one non-duplicate NTS were examined by PCR for plasmid mediated ESBL(TEM,SHV,OXA,CMY,and CTX-M-9),fluoroquinolone-resistance(qnr,aac(6’ )-Ib-cr,qepA and oqx) *** QRDR of topoisomerase genes (gyrA,gyrB,parC and parE) was also *** relatedness of isolates was determined by PFGE;susceptibility to antibiotics was measured with CLSI *** Numerous combinations of different antibiotic resistance genes and mutations in topoisomerase genes were *** most concern was that different isolates of Salmonella each contained several antibiotic resistance genes which together conferred high level resistance to extended spectrum(3 -lactams and *** These data suggest that contamination of food by multi-drug resistant bacteria in exporting countries with highly mobile populations will lead to global transfer of new antibiotic resistances from country to country by humans or on *** infections by such strains would be hard to treat.