Cysteinyl leukotriene D4 impairs mouse memory associated with Alzheimer's disease

作     者：TANG Su-su~1,HONG Hao~1,JIANG Li-ying~1,ZHANG Han-ting~2,LIU Li-ping~3,WANG Xiao-yun~1, HU Mei~1,ZHANG Ting-ting~1,LONG Yan~1,HU Wei~3,JI Hui~1,YE Feng-ying~1 (1.Department of Pharmacology,China Pharmaceutical University,Nanjing 210009,China 2.Department of Behavioral Medicine and Psychiatry,West Virginia University Health Sciences Center,Morgantown,WV 26506-9137 3.Department of Pharmacy,the Second Hospital Affiliated to Anhui Medical University Hefei 230031,China.) 

会议名称：《中国药理学会第十一次全国学术会议》

会议日期：2011年

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

关 键 词：Alzheimer’s disease cognition LTD4 CysLT1 receptor 

摘      要：Amyloid plaques in the extracellular parenchyma consist mainly of amyloid-βpeptides(Aβ),one of the pathological hallmarks in Alzheimer’s disease(AD).In the present study,we investigated neuro-inflammation,amyloidogenesis,cognitive impairment following intracerebral injections of Leukotriene D4(LTD4) in *** results demonstrated that LTD4 produced memory impairment and formation of Aβ and Aβ both in vivo and in vitro,which were blocked by pranlukast,a cysteinyl leukotriene receptor 1 (CysLT1R) *** addition,LTD4 increased levels of CysLT1R expression,which was also blocked by *** results suggest that LTD4 plays an important role in the mediation of cognitive impairment and amyloidosis associated with AD via CysLT1 receptors,which may be a novel target for treatment of AD.