Surface-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry:Noble Metal Nanoparticles as Efficient Substrates for Forensic Applications
作者单位：Department of Chemistry and State Key Laboratory of Synthetic ChemistryThe University of Hong Kong
会议名称：《中国化学会首届全国质谱分析学术研讨会》
会议日期：2014年
学科分类：081704[工学-应用化学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0838[工学-公安技术] 0703[理学-化学] 100105[医学-法医学] 10[医学]
基 金：financially supported by Hong Kong Research Grants Council(General Research Fund,Grant No.HKU_704511P) the Special Equipment Grant(Grant No.SEG_HKU02) the University Grant Council(Hong Kong SAR,China)
关 键 词：Surface-assisted Laser Desoprtion/lonization-Mass Spectrometry Imaging Mass Spectrometry Noble metal nanoparticles Forensic science
摘 要：Chemical analysis of forensic evidence collected from a crime scene is important for criminal *** uniqueness and specificity of chemical information obtained from the forensic sample is critical for successful *** Mass Spectrometry(IMS)is a powerful analytical technique which allows direct chemical analysis of forensic samples without extensive sample *** high sensitivity and specificity,the chemical identity and the spatial distributions of analytes in the sample will be ***,nanomaterials have been used in Surface-Assisted Laser Desorption/Ionization(SALDI)-based MS and IMS as substrate for forensic sample *** have applied Gold Nanoparticles(AuNPs)as efficient LDI substrate in previous *** samples including latent fingerprint and questioned documents were firstly coated with a layer of AuNPs using solvent-free Argon Ion Sputtering,followed by the subsequent spectrometric *** imaging of latent fingerprint can be *** latent fingerprint can be optically visualized due to the plasmonic properties of ***-and endogenous compounds found on latent fingerprint can also be molecularly imaged by *** document such as cheque with suspicious altered writing can be examined through the minimally-destructive ink analysis by *** using different pens can be distinguished by the MS images targeting different characteristic ions with specific m/z ***,altered words can be identified on the questioned *** team is developing other noble metal nanoparticles,such as silver nanoparticles(AgNPs),platinum nanoparticles(PtNPs),palladium nanoparticles(PdNPs)and bimetallic nanoparticles with welldefined physiochemical properties as potential efficient substrates for SALDI-MS and-IMS *** anticipate that the use of nanoparticles as substrate will enhance the analytical performance and extend the application in forensic science.