Biosynthesis of the thiopeptide antibiotic thiostrepton from Streptomyces laurentii

作     者：Haibin Deng, Ben Shen, Gongli Tang, and Wen Liu Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705 

会议名称：《The 3～(rd) International Conference on Natural Products :Natural Products -a Must for Human Survival ABSTRACTS》

会议日期：2004年

学科分类：08[工学] 082203[工学-发酵工程] 0822[工学-轻工技术与工程] 

摘      要：Thiostrepton is a member of the family of sulfur-rich peptide natural products known as the thiopeptide antibiotics, many of which exhibit broad spectra of antimicrobial activities and are clinically used as veterinary drugs. Recently, studies have been shown that thiostrepton inhibits protein synthesis in the blood stage of the malaria parasite at low concentrations. Although thiopeptide antibiotics may share the same mechanism of formation based on their high degree of sequence identity and structural similarity, the mode of biosynthesis of the thiopeptide antibiotics has not been clearly elucidated for any of the member of the family. Studying the unprecedented mechanism of thiostrepton will not only provide the biosynthetic platform to generate the structural diversity for drug discovery and development, but also contribute to the fundamental mechanisms of non-ribosome peptide synthase (NRPS) chemistry and enzyme catalysis, and eventually enrich the toolbox of combinatorial biosynthesis.