IFNbeta Induces secreted IL-1 receptor antagonist production through a MEK2/PI3Kdelta-dependent,ERK1/2-Independent pathway in human monocytes
作者单位：University of GenevaSwitzerland University of CaliforniaSan FranciscoUSA
会议名称：《21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology》
会议日期：2009年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
摘 要：The secreted form of IL-1 receptor antagonist(sIL-1Ra) is a natural inhibitor of the pro-inflammatory cytokine IL-1beta and therefore plays an important part in the regulation of inflammatory *** human monocytes,IFNbeta induces the production of slL-1Ra through the activation of PIsK but not of its canonical STAT *** used RNA interference and kinase