Small molecules regulate homeostasis of cytokines for suppression of pulmonary fibrosis and tumor metastasis
作者单位：Protein & Peptide Pharmaceutical LaboratoryInstitute of BiophysicsChinese Academy of Sciences
会议名称：《第二届全国“跨学科蛋白质研究”学术讨论会》
会议日期：2008年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Pulmonary fibrosis Lung metastasis Naringenin TGF-β1 Antifibrosis Antimetastasis Treg.
摘 要：Increasing evidence points to involvement of the fibrotic microenvironment in cancer initiation and progression. Here we demonstrate that mice with lung fibrosis challenged with tumors show an increased incidence of lung metastasis and shorter life spans.A fibrotic environment in the lung results in increased abundance of TGF-β1 and CD4+CD25+FoxP3+regulatory T cells and a decreased proportion of activated effector T *** grave immunosuppressive environment favors tumor localization and growth. Naringenin significantly reduces lung metastases in mice with pulmonary fibrosis and increases their survival by improving the immunosuppressive environment through downregulating TGF-β1 and reducing levels of regulatory T *** together,these data indicate that naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis.