Liver cancer-induced myeloid derived suppressive cells promote tumor metastasis and immune escape
作者单位：National Key Laboratory of Medical Immunology & Institute of ImmunologySecond Military Medical University
会议名称：《第九届全国免疫学学术大会》
会议日期：2014年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：MDSCs immune escape tumour metastasis MMP-9 IL-6
摘 要：Immune tolerance plays an essential role in the maintenance of immune *** with excessive or prolonged immune activation in the host during inflammation,autoimmune diseases or other immuno-pathologic situations,the immune system has development feedback mechanisms to inhibit immune over-activation and prevent inflammatory *** generation and expansion of immune suppression cell population is one of these *** suppressor cells,with the myeloid makers CD11bGr-1in mice and CD34CD33CD15CD13in human,represent aheterogeneous population of suppressor cells both in tumour-related and tumour-unrelated situations:infection with viruses,bacteria,fungi,and parasites;during immune stress caused by exposure to superantigens or recombinant vaccines;following myelosuppressive treatments by either cyclophosphamide or *** are potent inactivator in CD4and CD8T cells,which are responsible for inhibition of immune over-activation in inflammation and promotion of immune escape in tumour ***,little is known about the differences of MDSCs in immune-activated situation and tumour associated *** describe here a new cell population differented from common MDSCs in tumour mass,Liver cancer-induced MDSC(Li-MDSC),have more powerful potential in immune suppression and induction tumour metastasis by producing *** new cell subset is identified by secreting IL-6 and responsible for tumour induced immune escape and tumour metastasis.