DNA Repair Gene Polymorphisms in the Nucleotide Excision Repair Pathway and Lung Cancer Risk:A Meta-analysis
会议名称：《2012贵州省医学会胸心血管外科年会》
会议日期：2012年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
关 键 词：Nucleotide excision repair Polymorphism Lung cancer Meta-analysis
摘 要：Objective:A number of studies have reported the association of XPA,XPC,XPD/ERCC2 gene polymorphisms with lung cancer ***,the results were *** clarify the impact of polymorphisms of XPA,XPC,XPD/ERCC2,on lung cancer risk,a meta-analysis was performed in this study. Methods:The electronic databases PubMed and Embase were retrieved for studies included in this meta-analysis by XPA,XPC,XPD/ERCC2,lung,cancer/neoplasm/tumor/carcinoma, polymorphism(An upper date limit of October,31,2009).A meta-analysis was performed to evaluate the relationship among XPA,XPC and XPD polymorphism and lung cancer risks. Results:A total of 31 publications retrieved from Pubmed and Embase included in this *** A939C CC genotype increased lung cancer risk in total population(recessive genetic model:OR=1.23,95%CI:1.05-1.44;homozygote comparison:OR=1.21,95%CI:1.02-1.43and CC *** contrast:OR=1.25,95%CI:1.06-1.48), except in *** A751C,751C allele and CC genotype also increased lung cancer risk in total population and in Caucasians(recessive genetic model:Total population:OR=1.20,95%CI:1.07-1.35).No significant correlation was found between XPD A751C and lung cancer risk in Asians and African *** G312A AA genotype increased lung cancer risk in total population,in Asians and Caucasians(recessive genetic model:Total population:OR=1.20,95%CI:1.06-1.36).No significant association was found between XPA G23A,XPC C499T,XPD C156A and lung cancer risk. Conclusion:Our results suggest that the polymorphisms in XPC and XPD involve in lung cancer *** polymorphisms is less related to lung cancer risk.