Three Different Functional Microdomains in the Hepatitis C Virus Hypervariable Region 1(HVR1 ) Mediate Entry and Immune evasion
作者单位：里尔大学巴斯德研究所感染与免疫中心 斯特拉斯堡大学 马里兰大学医学院药理与实验药物治疗研究室
会议名称：《2012全国临床微生物与感染免疫学术研讨会》
会议日期：2012年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
关 键 词：Hepatitis C Virus Hype rvariable Region 1 Virus entry Immune evasion
摘 要：High genetic heterogeneity is an important characteristic of Hepatitis C virus(HCV) that contributes to its ability to establish persistent *** hypervariable region 1(HVR1) that comprises the first 27 amino acid residues of the E2 envelope glycoprotein is the most variable region within the HCV *** plays a major role in both HCV cell entry and immune evasion,but the respective contribution of specific amino acid residues is still *** mutagenesis analyses of HCV pseudoparticles(HCVpp) and cell culture-derived HCV (HCVcc) using the H77 isolate indicate that five residues at positions 14,15 and 25-27 mediate binding of the