A novel peptide targeting integrinαvβ3-rich tumor cells by magnetic resonance imaging

作     者：wu guoqiu Center of Clinical Laboratory Medicine of Zhongda Hospital Institute of Biotechnology and Clinical Pharmacy,Southeast University 

会议名称：《中华医学会第九次全国检验医学学术会议暨中国医院协会临床...》

会议日期：2011年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：Purpose To investigate targeting activity of the peptide(named P1c) derived from connective tissue growth factor(CTGF) toαvβ3-rich tumor cells. Materials and Methods P1c was synthesized and conjugated with ultra superparamagnetic iron oxide particles(USPIOs) coated with meso-2, 3-dimercaptosuccinic acid(DMSA).The specific binding activity of P1c-USPIOs toαvβ3 was