Study on the Upstream Effectors of NF- B/PKC/JNK and PI3K/PDK1/PP2A/eEF2Pathways for Tylophorine Elevated c-Jun Protein Level in Carcinoma Cells
作者单位：National Health Research Institutes
会议名称：《第十四届全国中药和天然药物学术研讨会》
会议日期：2014年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：funded by the National Science Council of Taiwan(NSC 102-2628-B-400-002-MY3) the National Health Research Institutes,Taiwan,R.O.C
摘 要：正Tylophorine,the major active constituent of Tylophora indica,has been reported to exhibit significant anti-cancer activities in vitro and in *** we reported that tylophorine elevated c-Jun protein level through two independent pathways,NF-B/PKC/JNK and PI3K/PDK1/PP2A/eEF2,to promote G1 arrest in carcinoma cells(Carcinogenesis,Yang,et al,