Design,Synthesis and Biological Evaluation of Piperidine Substituted DAPY DV-1 NNRTIs
作者单位：Rega Institute for Medical ResearchK.U.LeuvenMinderbroedersstraat 10B-3000 LeuvenBelgium
会议名称：《2011年全国药物化学学术会议——药物的源头创新》
会议日期：2011年
学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学]
关 键 词：HIV-1 NNRTIs DAPY Piperidine Antiviral activity
摘 要：正Diarylpyrimidine（DAPY） derivatives,one family of HIV-1 non-nucleoside reverse transcriptase inhibitors（NNRTIs） with excellent potency against wild-type and mutant strains of HIV-1,have attracted considerable attention over the past few ***,a series of piperidine linked aminopyrimidine derivatives was reported with good potency in both enzyme and antiviral assays,