Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model
作者单位：Departments of Biochemistry and Molecular BiologyThe University of Oklahoma Health Sciences Center
会议名称：《2012·中国医师协会中西医结合医师大会第三次会议》
会议日期：2012年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：sponsored by the National Natural Science,Foundation of China(81073097) the Developmental Fund of Chen Keji Integrative Medicine(CKJ 2011001) the Natural Science Foundation of Fujian Province of China(2010J01195)
关 键 词：Pien Tze Huang Chinese medicine colorectal cancer STAT3 pathway apoptosis proliferation
摘 要：Signal transducer and activator of transcription 3(STAT3) plays a critical role in cell survival and *** activation of STAT3 is strongly correlated with pathogenesis of various types of malignant tumor including colorectal cancer(CRC),and therefore becomes a major focus in the development of anti-cancer *** Tze Huang(PZH),a well-known traditional Chinese formula prescribed 450 years ago in the Ming Dynasty,has been demonstrated to be clinically effective in the treatment of ***,the precise mechanism of its anti-cancer activity remains largely unknown. In present study we evaluated the efficacy of PZH against tumor growth in vivo in the CRC mouse xenograft model,and investigated the underlying molecular *** found that administration of PZH reduced tumor volume and tumor weight but had no effect on body weight gain in CRC mice, demonstrating that PZH can inhibit colon cancer growth in vivo without apparent adverse *** also observed that PZH treatment inhibited the phosphorylation level of STAT3 in tumor ***, the inhibitory effect of PZH on STAT3 activation resulted in the up-regulation of Bax/Bcl-2 ratio as well as down-regulation of Cyclin D1 and CDK4 expression,leading to the induction of apoptosis as well as the inhibition of cell *** results suggest that promotion of cancer cell apoptosis and inhibition of proliferation via suppression of STAT3 pathway might be one of the mechanisms by which PZH treats colorectal cancer.