Liquiritigenin inhibits amyloid β-peptide-induced neurotoxicity,the secretion of amyloid β-peptide as well as fibril formation in vitro
会议名称:《2008年全国抗衰老与老年痴呆学术会议》
会议日期:2008年
学科分类:1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
关 键 词:liquiritegenin selective ERβagonist neuroprotective Aβsecretion fibil formation
摘 要:Background and Purpose:Amyloidβ-peptide(Aβ)is a pivotal pathological factor in Alzheimer’s disease(AD).Estrogen is beneficial to patients with AD but its proliferation and oncogenic effects on non-neuronal cells has dampened the enthusiasm for the use of estrogen