Antiflammin-1 inhibits the proliferation of lung fibroblasts via mediation of UGBP in vitro

作     者：Jing Wan,Wei Liu,Chen Li,Shengtian Cao,Dandan Feng,Jianzhong Han,Shaojie Yue,Xiaohong Liao,Ziqiang Luo(Department of physiology,Xiangya School of Medicine,Central South University,Changsha,Hunan) 

会议名称：《传承与发展，创湖南省生理科学事业的新高——湖南省生理科学会2011年度学术年会》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.30670770 30870916) 

关 键 词：UGBP,AF 1,TGF β1,cell cycle,cyclinD1,p27,NIH3T3 

摘      要：Objective To study the effect of Antiflammin-1(AF-1)on proliferation of lung fibroblast,and the mechanism of uteroglobin binding protein(UGBP)in mediating the anti-proliferation effect of AF-1 on lung fibroblasts. Methods NIH3T3 were cultured and divided into 8 groups with different ***-ELISA was used to detect cell proliferation of *** change of cell cycle was measured by flow ***-PCR and flow cytometry