Accentuation of ANP secretion by physcion via L-type Ca2+ channels in isolated perfused beating rabbit atria
作者单位：Institute of AtherosclerosisTaishan Medical University Institute of Materia MedicaTaishan Medical University
会议名称：《中国生理学会第24届全国会员代表大会暨生理学学术大会》
会议日期：2014年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by a research grant from the National Natural Science Foundation of China (81270920)
关 键 词：Physcion atrial natriuretic peptide secretion L-type Ca2+ channels atrial dynamics
摘 要：Objective:Physcion,an active anthraquinone constituent isolated from the rhubarb,a traditional Chinese herbal medicine which is widely used in clinical treatment,has cardiovascular protective ***,it remains unclear whether the cardiovascular protective actions of physcion are related to an activation of cardiac natriuretic hormone *** purpose of the present study was to explore the effect of physcion on the secretion of atrial natriuretic peptide（ANP）,a first member of the family of cardiac natriuretic hormones,and its mechanisms ***:Experiments were performed in perfused beating rabbit left *** changes in ANP were measured by a specific *** changes in atrial mechanical dynamics,atrial stroke volume and pulse pressure,were chased during the ***:Physcion increased ANP secretion concomitantly with a decrease in atrial pulse pressure and stroke volume in a concentration-dependent ***-induced changes in ANP secretion and atrial dynamics were attenuated by inhibition of L-type Ca2+channels with ***,methoctramine and tertiapin-Q had no significant effect on the Physcion-induced changes in ANP secretion and mechanical ***:These findings indicate that physcion increases ANP secretion via inhibition of L-type Ca2+*** results also provide a rationale for the use of emodin in the treatment of impairment of the regulation of the cardiovascular homeostasis.