Ca2+ Signaling: From Cardiovascular Function to Apoptosis and Cancer Biology
作者单位：Department of Physiology and Biophysics UMDNJ-Robert Wood Johnson Medical School 675 Hoes Lane Piscataway NJ 08854. Cleveland Clinic Foundation Case Western Reserve University Kwanju Institute of Science and Technology (Korea) Tohoku University (Japan)
会议名称：《第九次全国生物物理大会学术会议》
会议日期：2002年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Ca ions are important second messengers in many signal transduction pathways. They participate inessentially every cellular processes, ranging from gene regulation and protein trafficking, to cell differentiationand apoptosis, and to membrane excitability and cell motility. In general, there are two sources of thesesignaling molecules in the cell:channels in the plasma membrane (PM) that open to allow external Ca toflow into the cytoplasm, and internal stores in the form of endoplasmic reticulum (ER) or sarcoplasmicreticulum (SR) that release Cainto the cytosol. Junctional membrane complexes between PM and ER/SR arepresent in all excitable cells, and provide effective mechanism for cross-talk between Ca-dependentchannels/transporters on the plasma membrane and Ca release channels on the intracellular membrane.