Design,synthesis,and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins:Characteristics of broad-spectrum protein binding and its effects on anti-tumor activity

作     者：Can-Hui Zheng,Hui Yang,You-Jun Zhou~*,Ju Zhu~* School of Pharmacy,Second Military Medical University,325 Guohe Road,Shanghai,China 

会议名称：《2011年全国药物化学学术会议——药物的源头创新》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 100701[医学-药物化学] 10[医学] 

摘      要：The anti-apoptotic members of the Bcl-2 protein family have become attractive targets for anti-cancer drug development,and broad-spectrum small-molecule inhibitors targeting it may be ideal anti-cancer *** the basis of the comparison of the structure of the Bim BH3:Bcl-x complex and that of the ABT-737:Bcl-x complex,a series of class A compounds were *** compounds