Apolipoprotein A-I Inhibits LPS-Induced As in ApoE-/-Mice through Activation of STAT3 and Upregulation of Tristetraprolin
作者单位：From Institute of Cardiovascular ResearchKey Laboratory for Atherosclerology of Hunan ProvinceLife Science Research CenterUniversity of South China Department of DiagnosticsThe Medical CollegeUniversity of South China Department of pathologyNan Xian Peoples Hospital Department of Nutrition SciencesUniversity of Alabama at BirminghamBirminghamAL 35294-0012USA
会议名称：《第11届全国脂质与脂蛋白学术会议》
会议日期：2012年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：Aims:Apolipoprotein A-I(apoA-I),the major component of high-density lipoprotein(HDL),can suppress the lipopolysaccharide(LPS)-induced inflammatory response in *** role of apoA-1 in LPS-induced atherosclerosis in vivo, however,has not been *** the current study,we investigated the effect and mechanism of apoA-I on the development of atherosclerosis in LPS-challenged apoE-/- mice.