The Interaction Between Pazufloxacin and Calf Thymus DNA Mediated by metal ions

作     者：Wang Guo-Ping, Chen Shu-Yang Department of Chemistry, Zhejiang University, Hangzhou, 310027 

会议名称：《中国化学会第四届有机化学学术会议》

会议日期：2005年

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

摘      要：正The nature and dynamics of binding drug molecules to nucleic acids represent an active area of investigation. The interest of this field is diverse, since metal ions are found to play an important role in the DNA and RNA structure, as well as in relation to the different process in which these macromolecules are involved . Quinolones are an important group of antibiotics and several quinolones are in common clinical use. The carboxylic acid at position 3 and the exocyclic oxygen at position 4 are believed to be the portion of the molecule that binds to the DNA gyrase of the