Rap2-induced migration of renal cancer cell Caki-1 is mediated by JNK
作者单位：The Department of Life Science and EngineeringHarbin Institute of Technology
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议》
会议日期：2010年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Rap2,a Ras family small GTPase regulates a variety of cellular functions including cell proliferation,adhesion and migration through activating its downstream effectors Raf,MAP4K4,TNIK,PARG,*** these factors, MAP4K4,a member of STE20 family kinase is involved in the regulation of cell migration of multiple cancer cell lines. JNK,a downstream target regulated by MAP4K4 is found to correlate to the promoted migration of many carcinoma *** quiescent states,the inactivated JNK distributes over cytoplasm and nucleus,and once activated it translocates to the nucleus as well as to the plasma membrane,regulating