Astragaloside Ⅳ prevents the mitochondrial permeability transition pore opening by inhibiting GSK-3β via nitric oxide in H9c2 cardiac cells
会议名称：《第十三次全国心血管病学术会议》
会议日期：2011年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
摘 要：Objectve AstragalosideⅣ,a major ingredient of traditional Chinese herb Radix Astragali,has been widely used for treatments of cardiovascular diseases in China,but the exact cellular and molecular mechanisms underlying its action remain *** aim of this study was to investigate whether astragalosideⅣmodulates the mitochondrial permeability transition pore(mPTP) opening through glycogen synthase kinase 3β(GSK 3β) in cardiac H9c2 *** H9c2 cells were exposed to astragalosideⅣfor 20 ***-3β(Ser9),Akt(Ser473),and VASP(Ser239) activities were determined by