Purine-mediated signaling in Glial Cells
作者单位：Zhejiang University School of Medicine
会议名称：《细胞—生命的基础——中国细胞生物学学会2013年全国学...》
会议日期：2013年
学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学]
摘 要：Glial cells can release signal molecules that mediate intercellular communication.In particular,ATP release from astrocytes is required for Ca wave propagation among astrocytes and for feedback modulation of synaptic functions.We found that lysosomes in astrocytes contain abundant ATP and their partial exocytosis resulted in a low-level ATP release,whereas full exocytosis led to the release of a larger amount of ATP,together with lysosomal enzymes.Repetitive neuronal activity induces release