Intronic Deletions of the tva receptor gene Decreased Susceptibility to Infection by Avian Sarcoma and Leukosis Virus Subgroup A
作者单位：College of Animal ScienceSouth China Agricultural University College of Veterinary MedicineShandong Agricultural University Institute of Animal HusbandryGuangdong Academy of Agriculture Sciences USDAAgriculture Research ServiceAvian Disease and Oncology Laboratory
会议名称：《中国畜牧兽医学会动物微生态学分会第十一次全国学术研讨会暨第五届会员代表大会》
会议日期：2014年
学科分类：090601[农学-基础兽医学] 09[农学] 0906[农学-兽医学]
关 键 词：Avian sarcoma and leukosis viruses tva receptor gene intronic deletion decreased susceptibility Chinese chickens
摘 要：The avian sarcoma and leukosis virus(ASLV) family of retroviruses contains six highly related subgroups,A to E and J,thought to have evolved from a common viral ancestor in *** susceptibility or resistance of host cells to the ASLV subgroups is determined by the tva,tvb,tvc and tvj receptor genes,*** prevalence of ASLV in host might have imposed strong selection pressure toward resistance or at least decreased susceptibility to ASLV infection,and the resistant alleles in all four receptor genes have been *** this study,two new alleles of the tva receptor gene with similar intronic deletions were discovered in Chinese commercial *** natural mutations delete a putative splice branch point consensus sequence,leading to the retention of the intron I and introducing premature TGA stop codons *** shorter and longer tva *** analysis demonstrated that the observed decreased susceptibility to subgroup A ASLV in vitro and in vivo is the result of the inefficient splicing of tva *** study illustrated that defective splicing of the tva receptor gene can confer the genetic resistance of host to subgroup A ASLV.