Synthesis and Structure - Activity Relationship Studies in Disruptors of p53-MDM2 Interaction Based on a 3,4,5-trisubstituted Aminothiophene Scaffold

作     者：Weisi Wang and Yongzhou Hu~* ZJU-ENS Joint Laboratory of Medicinal Chemistry,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China '' 

会议名称：《2011年全国药物化学学术会议——药物的源头创新》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by NSFC(30873163) 

摘      要：正The first identified tumor suppressor p53 is a potent transcription factor which plays a key role in induction of cell cycle arrest,apoptosis and ***-of-concept experiments have demonstrated that blocking the p53-MDM2（a master negative regulator of p53） interaction can effectively reactivate wild-type p53 in tumor cells leading to their death,which is now recognized