Synthesis and Structure - Activity Relationship Studies in Disruptors of p53-MDM2 Interaction Based on a 3,4,5-trisubstituted Aminothiophene Scaffold
会议名称:《2011年全国药物化学学术会议——药物的源头创新》
会议日期:2011年
学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金:Supported by NSFC(30873163)
摘 要:正The first identified tumor suppressor p53 is a potent transcription factor which plays a key role in induction of cell cycle arrest,apoptosis and ***-of-concept experiments have demonstrated that blocking the p53-MDM2(a master negative regulator of p53) interaction can effectively reactivate wild-type p53 in tumor cells leading to their death,which is now recognized