MECHANISM OF ACTION OF FLUORIDE ON BONE CELLS’ AND BONE TISSUE
作者单位：Division of Clinical PathophysiologyDepartment of MedicineUniversity Hospital Geneva1211 Geneva 14Switzerland.
会议名称：《第一届国际骨质疏松和代谢性骨病研讨会》
会议日期：1992年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：正It is well documented that fluoride when given to osteoporotic subjects has the ability to increase spinal bone *** effect appears to be mainly due to an increased amount of trabecular bone,Histomorphometric data indicate that fluoride increases trabecular volume via an increase in both the number of osteoblasts and the formation period of the bone remodeling *** positive effect does not appear to be fully translated into a commensurate increment in bone ***,fluoride treatment may also decrease the osteoblastic activity that determines the amount of bony substance layed down per cell and unit ***,the concept of an increase of bone formation at the tissue level but not at the cellular *** differential effect could be dependent upon the bone fluoride content.