Study on the Synthesis and application of 4,6-bis(diphenylphosphino)phenoxazine
作者单位：Institute of Chemistry Henan Academy of Sciences
会议名称：《河南省化学会2016年学术年会》
会议日期：2016年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
关 键 词：4,6-bis(diphenylphosphino)phenoxazine cross-coupling organic phosphorus
摘 要：4,6-bis(diphenylphosphino)phenoxazine was an important organic phosphorus ligand. It was widely used in hydroformylation, Palladium-catalyzed cross-coupling reaction, and C-H bond activation.4,6-bis(diphenylphosphino) phenoxazine was synthesized through protected by tertbutyldimethylsilyl chloride, introducing diphenylphosphine and off-protecting in 62% total yield. In the first step the solvent was THF, the temperature was 75 °C and n(phenoxazine):n( NaH):n( tertbutyldimethylsilyl chloride) = 1:1.25:1.5. In the second step the solvent was diethyl ether, and n(compound II):n( n-Bu Li):n( Ph2PCl):n( TMEDA) = 1:2.4:2.4:2.4. The protection group was removed with tetrabutylammonium fluoride in 24 h.