CORRELATION BETWEEN VITAMIN E AND ZOCAR LEVELS AND THE DEVELOPMENT OF ALZHEIMER’S DISEASE IN A MOUSE MODEL OF AD
作者单位：Iran university of medical science. Tehran university of medical science.
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学]
关 键 词：Alzheimer s disease vitamin E + Zocar
摘 要：正 Alzheimer’s disease（AD）is the most common type of dementia（ 75% ）. manifesting as a severe deterioration of mental functions. The brains of people with Alzheimer Disease exhibit deposition of amyloid - B and progressive degeneration of nerve *** are studing ways that may help decrease or prevent neurodegeneration and may help injured neurons to regrow. We determined whether the antioxidant vitamine E + ZOCARaffected the presence of amyloid plaques in brain of aged PDAPP transgenic mice. Beta - amyloid precursor protein （APP）. is important for the pathogenesis of Alzheimer’ s disease （AD）,which is characterized by progressive decline of cognitive functions,formation of A beta plaques,and neurofibrillary tangles,and loss of *** the present study we have examined that treatment by vitamin E + Folic acid in PDAPP aged mice compare with control groups is able to decrease 17 % in AB plaques levels of cerebral amyloidosis in necortex. More over,our results suggest that treatment by vitamins is able to prevent the disruption of basal cholinergic forebrain system and prevent of loss of cholinergic basal forebrain neurons（ Ms + HDB,VDB）.