Principles of organization and function of locomotor microcircuits in zebrafish
作者单位：Department of NeuroscienceKarolinska Institutet
会议名称：《中国神经科学学会第十届全国学术会议》
会议日期：2013年
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
摘 要：Motor behavior represents the overt expression of the processing in the brain.A salient feature of motor behavior is the orderly recruitment of motor pools and the coordination of their activity to produce movement with precise force,speed and *** spinal networks generate the basic locomotor pattern and also act as a processing interface to adjust their output in response to influences from the brain and sensory *** natural variability in the speed of locomotion requires an orderly recruitment of motoneurons from those innervating slow to those innervating fast muscle *** research aims at understanding the rule governing the recruitment of essential neuronal elements in the locomotor *** far,our analysis has focused on the output stage by describing the mechanisms dictating the threshold of recruitment of motoneurons and a class of excitatory interneurons during swimming in adult *** results show that motoneurons are organized in four pools with specific topographic locations and are incrementally recruited to produce swimming at different *** recruitment threshold is set by a combination of specific intrinsic properties of motoneurons and the strength of their synaptic currents,but does not rely on their input *** contrast to motoneurons,no topographic organization was apparent for the recruitment of excitatory interneurons at different swimming *** findings indicate that the locomotor networks are composed of ensembles of microcircuits that are recruited sequentially to cover the full range of swimming frequencies.