N-Heterocyclic Carbene-Catalyzed[4+2]Cyclization of α-bromo-enal with 3-alkylenyloxindoles:an efficient synthesis of spirocyclic oxindoles
作者单位：School of Chemistry and Chemical EngineeringJiangsu Normal University
会议名称：《中国化学会全国第十一届有机合成化学学术研讨会》
会议日期：2014年
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：financial support by National Natural Science Foundation of China(21372101)
关 键 词：NHC spirocyclic oxindole α-bromo-enal 3-alkylenyloxindole
摘 要：N-heterocyclic carbene(NHC) catalyzed reactions have emerged as an particularly fruitful area of research in organic chemistry. Due to the unique Umpolung in organic synthesis,umpoluping the aldehydes to acyl nucleophiles has become an important way to synthesis of heterocyclic compounds in current research. Spirooxindole cores are interesting and important structures found in many bioactive natural products,and the functionalized six-membered spirooxindole core structure is featured in many natural products as well as medicinally relevant compounds. Herein we shall report our preliminary results of an NHC-catalyzed reaction of 2-bromo-2-enal bearing γ-H with 3-alkylenyloxindoles,which may give the desired spirocarbocyclic oxindoles with potential bioactivity.