Synthesis,characterization and anticancer activity of anthracene-9-pyridylhydrazone and its Cu（Ⅱ）,Co（Ⅲ）,Ni（Ⅱ） complexes
作者单位：State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal ResourcesSchool of Chemistry ＆ Pharmacy of Guangxi Normal University
会议名称：《中国化学会全国第十二届有机合成化学学术研讨会》
会议日期：2015年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 100701[医学-药物化学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the Natural Science Foundation of China(No.21271051,81473102,21431001) IRT1225 Natural Science Foundation of Guangxi Province(No.2013GXNSFAA019044) Foundation of State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2012-A11/2013-C05)as well as‘‘BAGUI Scholar’’program of Guangxi Province of China
关 键 词：Schiff base anthracene hydrazone metal complex antitumor activity
摘 要：A Schiff base ligand,anthracene-9-pyridylhydrazone（9-APH）,was synthesized by 9-anthracencarboxaldehyde and 2-hydrazinopyridine,and was characterized by UV,ESI-MS,1H-NMR and *** transition metal complexes 1-3 of 9-APH were synthesized and structurally characterized as *** in vitro antitumor activity of 9-APH and its metal complexes were screened by MTT method against five tumor cell lines（MGC80-3,NCI-H460,SK-OV-3,Hep-G2,BEL-7404） as well as the normal liver cell line *** 2 showed some higher cytotoxicity towards most of the tumor cell lines than 9-APH,but lower cytotoxicity toward the HL-7702 cell,suggesting their cytotoxic selectivity on the tumor cells.