Synthesis and Antitumor Activity of Novel 4,5-Disubstituted 1,3- Thiazole Imine Derivatives

作     者：Jiao Ye,Wen-Jing Xuan,Ai-Xi Hu~*,Zhi Qin College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,Hunan, People''s Republic of China 

会议名称：《2011年全国药物化学学术会议——药物的源头创新》

会议日期：2011年

学科分类：1007[医学-药学(可授医学、理学学位)] 100701[医学-药物化学] 10[医学] 

基　　金：Supported by the National Project of Scientific and Technical Supporting Programs and Ministry of Science & Technology of China(No.2011 BAE06B01) 

关 键 词：4-tert-butyl-5-benzyl-2-benzyliminothiazole synthesis antitumor activity 

摘      要：正A series of novel 4-tert-butyl-5-benzyl-2-benzyliminothiazole derivatives were synthesized by reaction of substituted benzaldehydes with 2-Amino-4-tert-butyl-5-sustituted benzyl thiazole and characterized by elemental analysis and 1H *** newly synthesized compounds were screened for their antitumor activities against three human cancer cell lines in vitro,namely HELA（cervical）,BEL 7402（liver）,and CNE 2（nasopharyngeal） cancer cell *** bioassay results showed that some of the compounds possess promising antitumor *** IC50 values of them were 3d（0.007 mmol/L） and 3f（0.001 mmol/L） against HELA,3j（0.006 mmol/L） against BEL 7402,3d（0.009 mmol/L）,3f（0.004 mmol/L）,3g（0.001 mmol/L） and 3m （0.002 mmol/L） against CNE 2,respectively.