Protective Roles of SIRT1 in Vascular Diseases
会议名称：《第八届海峡两岸心血管科学研讨会》
会议日期：2011年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
摘 要：正Accumulating evidence reveals that aging is a major risk factor for cardiovascular disease（CVD）. Sirtuin 1（SIRT1）,the closest homology to the yeast Sir2 protein in human sirtuins,has been implicated in aging,metabolism,and tolerance to oxidative stress via its ability to deacetylate a variety of substrates,including histones,transcription factors,and *** recent studies have demonstrated that SIRT1 is an anti-atherosclerosis factor and prevents the hyperglycemia - induced endothelial ***,SIRT1 acts as a modulator of neointima formation following vascular injury in *** summarized the beneficial effects of SIRT1 in vascular system and proposed that SIRT1 and its activators can become novel therapeutic targets for age - related vascular diseases.