EFFECT OF ELECTRET ON TRANSDERMAL PERMEATION OF MELOXICAM FROM A PATCH FORMULATION

作     者：Jiang Jian~1,Kong Yuxiu~2,Cheng Liang~1,Hou Xuemei~2,Liang Yuanyuan~1,Wang Dong~2,Xiao Yongheng~2, Cui Lili~(2*) Department of Physics and Mathematics,Faculty of Basic Medical Sciences,Second Military Medical University,Shanghai,200433,China Department of Inorganic Chemistry,School of Pharmacy,Second Military Medical University,Shanghai, 200433,China 

会议名称：《The 6th International Conference on Applied Electrostatics》

会议日期：2008年

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Sponsored by research foundation of PLA of China, No.06H022 Sponsored by Natural Science Foundation of China, No.50577066 

关 键 词：electret meloxicam transdennal delivery patch 

摘      要：In this study,the effect of electret and 10%ethyl oleate on meloxicam skin permeation was studied by improved Franz diffusion cell,UV measurement and HPLC analysis. The results indicated that electret had better enhancing effect on the skin permeation of meloxicam than that of 10%ethyl ***, electret and 10%ethyl oleate had an incorporative effect that could lead to a stable transdermal flux of meloxicam of 6.531μg/cm·h and 79%of the drug permeating through the skin after applying the patch on skin for ***:electret meloxicam patch had better transdermal enhancing effect.