Antidepressant-and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats though inhibition of hippocampal oxidative stress
会议名称：《中国生理学会第24届全国会员代表大会暨生理学学术大会》
会议日期：2014年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100205[医学-精神病与精神卫生学] 10[医学]
关 键 词：Anxiety Depression Diabetes Hydrogen sulfide
摘 要：Depression is highly prevalent in individuals with diabetes and the depressive symptoms are less responsive to current antidepressant *** stress plays a major role in both the pathogenesis of diabetes and the major depression and anxiety *** sulfide(H2S),the third gaseous mediator,is a novel signaling molecule in brain and possesses the antioxidative role and the antidepressant-and anxiolytic-like *** hypothesized that H2S could produce the antidepressant-and anxiolytic-like activities in diabetic patients by its antioxidative *** test this hypothesis,we generated streptozotocin(STZ)Z-induced diabetic *** found that H2S alleviated depressive-like behaviors of STZ-induced diabetic rats in the force swimming and tail suspension tests and reduced anxiety-like behaviors of STZ-induced diabetic rats in the elevated plus maze *** also found that H2S significantly reduced the levels of malondialdehyde(MDA)and 4-hydroxynonenal(4-HNE)and elevated the levels of superoxide dismutase(SOD)and reduced glutathione(GSH)in thehippocampus of STZ-induced diabetic *** results provides evidence for antidepressant-like and anxiolytic-like effects of H2S in STZ-induced diabetic rats and the therapeutical effects may be due to inhibition of hippocampal oxidative *** findings suggest that elevating H2S signaling is a potential target for treatment of depressive and anxiety disorders related to diabetes.