Effect of Diagnostic and Treatment Delay on the Risk of Tuberculosis Transmission in Shenzhen,China:An Observational Cohort Study,1993-2010
作者单位：National Centre for Tuberculosis Control and PreventionChinese Center for Disease Control and Prevention Shenzhen Chronic Disease Control Centre Key Laboratory of Major Diseases in Children and National Key Discipline of PediatricsMinistry of EducationBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical University Bureau of Disease Control and PreventionMinistry of Health National Institute of Allergy and Infectious DiseasesU.S.National Institutes of Healthbased at the U.S.Embassy National Institute on Drug DependenceHealth Science CentrePeking University Takemi Program in International HealthDepartment of Global Health and PopulationHarvard School of Public HealthBostonMassachusettsUnited States of America
会议日期：2014年
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by National Nature Science Foundation(No.30973981) Beijing Municipal Commission of Education(No.KM201010025010) Chinese Government Grants(no.2012ZX10004903)
摘 要：Introduction:To understand better the risk of tuberculosis transmission with increasing delay in tuberculosis treatment,we undertook a retrospective cohort study in Shenzhen,***:All pulmonary tuberculosis cases in the Shenzhen tuberculosis surveillance database from 1993-2010 were *** smear positivity and presence of pulmonary cavity were used as proxies for risk of tuberculosis ***:Among 48,441 pulmonary tuberculosis cases,70%presented with symptoms of pulmonary TB,62%were sputum smear positive,and 21%had a pulmonary cavity on chest x-ray.95.3%of patients self-presented for evaluation of illness after a median 58 days of delay after symptoms *** proportion presenting sputum smear positive(p0.001) and with a pulmonary cavity(p0.001) increased significantly with increasing duration of ***:Delayed diagnosis and treatment of tuberculosis is associated with a significantly increased risk of pulmonary sputum smear positivity and pulmonary *** decrease risk of transmission,treatment delay needs to be reduced further.