SYSTEMS BIOLOGY AND METABOLIC ENGINEERING:MICROBIAL STRAIN IMPROVEMENT AND BIOPROCESS OPTIMISATION
会议名称：《首届国际生物经济高层论坛》
会议日期：2005年
学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 07[理学] 071005[理学-微生物学] 10[医学]
关 键 词：Systems biology metabolic engineering genome transcriptome proteome metabolome fluxome bioprocess
摘 要：正Systems biology studies biological systems by systematically perturbing them （biologically,genetically,chemically or physically）;monitoring the gene,protein, metabolite and informatical pathway responses;integrating these data;and ultimately, formulating mathematical models that describe the structure of the system and its response to individual *** engineering is the improvement of cellular properties by using modern genetic engineering *** engineering encompasses three important steps:the modification of cellular pathways（synthesis）,the rigorous evaluation of the phenotype of the modified cells（phenotype characterization） and optimization design of further genetic modification（design）.In the procedure,OMEanalyses play great roles in the phenotype *** the environmental conditions have also great effects on the cellular properties,so the changes of the cellular properties under different environmental conditions must be evaluated by theOME*** on theOMEanalyses,it is possible to get valuable knowledge that can be used for the development of metabolic engineering strategies,which consequently are used to optimize the *** this paper,we review the recent advances of metabolic engineering based on systems biology.