Novel Approaches for Inhibitor Screening and Target Identification using Arabidopsis Full-Length cDNA Overexpression (FOX) Lines
作者单位:RIKEN Plant Science CenterYokohama Japan RIKEN Plant Science Center Yokohama Japan
会议名称:《The 1st International Conference on Plant Secondary Metabolism》
会议日期:2008年
学科分类:0710[理学-生物学] 07[理学] 071007[理学-遗传学]
摘 要:正Organisms have two possible routes for the biosynthesis of isoprenoids;the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways.The MEP pathway has been recently recognized as important target of drug and agrochemical developments and chemical genetics studies,e.***.fosmidomycin shows antima- larial activity by inhibition of 1-deoxyxylulose-5-phosphate reductoisomerase (DXR),and clomazone has been used for herbicide,which metabolite ketoclomazone inhibits 1-deoxyxylulose-5-phosphate synthase.Plants have