Luteolin protects cortical neurovascular unit against amyloid β25-35 peptide-induced toxicity in mice

作     者：Rui Liu~1,Gui-Fen Qiang~1,Xi Lan~1,Li Zhang~2,Lin Li~2,Guan-Hua Du~(1*) (1.National Centre for Pharmaceutical Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100050,China 2.Pharmaceutical Institute,Xuanwu Hospital,Capital University,Beijing 100053,China 

会议名称：《中国药理学会第十次全国学术会议》

会议日期：2009年

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by National Natural Science Foundation of China(NO.30630073 30772749) 

关 键 词：neurovascular unit amyloidβpeptide blood-brain barrier luteolin 

摘      要：Alzheimer’s disease is the commonest cause of cognitive decline in *** major feature is the accumulation of amyloidβproteins in the brain both in the form of plaques in the cerebral cortex and in blood vessels. A growing number of studies have paid attention to the neurovascular coupling,which provides an essential clue for better understanding of physiologic and pathologic properties of the brain.