Genetic analysis of Parkinson’s disease gene Pink1 in Drosophila

作     者：Chang-An JIANG Department of Neurology University of California 

会议名称：《中国神经科学学会第四次会员代表大会暨第七届全国学术会议》

会议日期：2007年

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

摘      要：正Parkinson’s Disease（PD） is a common neurodegenerative disorder caused by selective loss of dopaminergic neurons in the substantia *** studies on familial forms of PD have led to the identification of six PD genes,but their biochemical functions are not *** dissect the defective molecular pathways in PD patients,we have generated Drosophila mutants for PTEN-induced kinase 1（Pink 1）,a PD gene encoding a putative mitochondrial ser/thr *** of Pinkl function causes male sterility,apoptotic muscle degeneration and increased sensitivity to oxidative *** phenotypes were accompanied by severe morphological defects in *** of another PD gene, Parkin,rescues Pink 1 mutant phenotypes and mitochondrial defects,suggesting that Parkin functions downstream of *** results implicate mitochondrial dysfunction as a key event in PD pathogenesis.