Maternal endotoxemia results in increases in blood pressure and body weight in rats
会议名称：《两岸三地药理学与临床药理学术会议》
会议日期：2008年
学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
关 键 词：hypertension inflammation obesity prenatal exposure
摘 要：Objective To investigate the effects of prenatal exposure to lipopolysaccharide (LPS) on blood pressure and body weight of offspring in *** Sixteen healthy pregnant rats were randomly divided into two *** rats in LPS group were injected intraperitoneally with LPS (0.79 mg·kg) at the 8,10,12 day of *** in the control group were only treated with *** delivery,all off- spring were weighed and blood pressure was measured by tail-cuff method once every two weeks from the 6 to 24 *** the 15 week,their food intakes were weighed every *** the end of the 24 week, the rats were put to death by *** adipose tissues were taken to weigh,and serum level of leptin was detected by *** The offspring with prenatal LPS exposure showed increased systemic arterial pressure,heavier body weight,elevated food intake,increased adipose tissue weight and increased circulating leptin compared with *** Prenatal exposure to LPS leads to increases in blood pressure and body weight in rats.