Synthesis of Novel Phosphoramide-Tegafur Derivatives Containing Aminopropylsilatrane

作     者：De Qing Shi Qi Chen ZhongHua Li Xiao Peng Liu College of Chemistry, Central China Normal University, Wuhan, P. R. China and Key Laboratory of Pesticide and Chemical Biology, Ministry of Education of China College of Chemistry, Central China Normal University, Wuhan, 430079 Hubei, China 

会议名称：《湖北省化学化工学会2006年年会暨循环经济专家论坛》

会议日期：2006年

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We are grateful to the key project of the Chinese Ministry of Education‘(02140) the dawn plan of science and technology for young scientists of Wuhan city(2002501024)for the financial support We are also indebted to Prof.Guanhua Du who works at Beijing Institute of Medicine in Academy of Medical Sciences of China for antitumor activities test 

关 键 词：Anti-tumor activity γ-aminopropyl silatrane pbosphoramide tegafur 

摘      要：A series of novel phosphoramide-tegafur derivatives containing γ-aminopropyl sila- trane were synthesized via the condensation reactions of phosphoryl dichloride with N1-(2-furanidyl)-N3-(hydroxyethyl)-5-fluorouracil, followed by condensation with γ-aminopropyl silatrane. The structures of the products were confirmed by 1HNMR, 31P NMR, IR, MS, and elemental analysis. The results of preliminary bioassay showed that the new compounds had an inhibition effect against HCT-8 and Bel- 7402 cell lines.