(-)-Epigallocatechin-3-Gallate Enhances Hepatitis C Virus DoubleStranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes
作者单位:Department of Infectious DiseasesShanghai Children’s HospitalShanghai Jiao Tong University Department of Pathology and Laboratory MedicineTemple University School of Medicine Deparment of MicrobiologyImmunologyand BiochemistryUniversity of Tennessee Health Science Center
会议名称:《中华医学会第七次全国艾滋病、丙型肝炎学术会议》
会议日期:2015年
学科分类:1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学]
关 键 词:HCV Epigallocatechin-3-Gallate Enhances Hepatitis C Virus DoubleStranded RNA Intermediates-Triggered Innate Immune Responses in Hepatocytes RNA
摘 要:(-)-Epigallocatechin-3-gallate(EGCG),a major polyphenol component of green tea,has recently been identified as an inhibitor of hepatitis C virus(HCV)***,we examined whether EGCG can enhance hepatocyte-mediated intracellular innate immunity against *** dsRNAs(Core,E1-P7,NS-3 NTR and NS5A)induced interferon-l1(IFN-l1)expression in human *** HCV