HP1 specifies the centromere localization of chromosomal passenger complex through its interaction with Borealin

作     者：Zhen Dou~(1,2),Zhenwei Song~2,Yuda Huo~(1,2),Xing Liu~(1,2),Tongge Zhu~(1,2),Yunyu Shi~2,Xuebiao Yao~(1,2) 1.Anhui Key Laboratory for Cellular Dynamics and Chemical Biology,and 2.Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences,University of Science & Technology of China,Hefci,Anhui 230026,China 

会议名称：《“细胞活动生命活力”——中国细胞生物学学会全体会员代...》

会议日期：2011年

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

关 键 词：centromere chromosomal passenger complex Borealin HP1 

摘      要：During cell division,chromosome segregation is orchestrated by the interaction of spindle microtubules with the *** attachment of spindle microtubules to kinetochore requires the chromosomal passenger of Aurora B kinase complex with Borealin,INCENP and ***,the chromatin factors that recruit the CPC to centromeres have remained *** we show that the C-terminal Borealin is directly recognized by an evolutionarily conserved binding motif PxVxL in the chromatin shadow domain of heterochromatin protein 1(HP1 ).This Borealin-HP1 binding mediates recruitment of the CPC to the centromere and the resulting activation of its kinase subunit Aurora B. Consistently,modulation of the binding motif PxVxL,leads to defects in CPC centromere targeting and Aurora B *** localization of CPC in midzone is independent of Borealin-HP1 *** findings establish a direct link between HP1 and CPC plasticity in centromere and its cellular role for *** in orchestrating an accurate cell division.