Target validation for cancer therapy using a conditional regulatable K-RasG12D mice allele
作者单位：Laboratory of Molecular Cell BiologyInstitute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of Sciences
会议名称：《中国生物化学与分子生物学会第十届会员代表大会暨全国学术...》
会议日期：2010年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Oncogenic K-Ras mutation,frequently observed in human cancers including pancreatic cancer,colorectal cancer and lung cancer,plays an essential role in cancer initiation and progression.K-Ras mutation is commonly accepted as an oncogenic driver.However,whether K-Ras mutant is a good target for cancer therapy and how K-Ras mutant impacts upon cancer maintenance still remain largely unknown.Here we construct a conditional inducible K-RasG12D knock-in mice allele that allows us to temporally switch on or off the K-Ras oncogenic mutant through the tamoxifen administration.